FK 506: Effects on glomerular hemodynamics and on mesangial cells in culture

Notes on FK 506.

Prostaglandin synthesis by rat glomerular mesangial cells in culture. Effects of angiotensin II and arginine vasopressin.

Arginine vasopressin (AVP) and angiotensin II (ANG II) reduce the glomerular filtration rate and ultrafiltration coefficient. Vasodilatory prostaglandins (PG) antagonize these effects. AVP and ANG II also cause mesangial cell contraction. Therefore, possible PG stimulation by these peptides and two vasopressin analogues was studied in cultured rat glomerular mesangial cells. The effect of alter...

Glomerular Mesangial Cells

Glomerular mesangial cell (MC)-derived IL-1 may be an important factor in the development of the hypercellularity and sclerosis characteristic of many forms of glomerulonephritis. To define the regulation of IL-I synthesis by human MC, Northern blot analyses were performed using specific probes for monocytic IL-1 a and 8 mRNA. Proliferating MC expressed mRNA for both IL-1 a and ft, whereas nonp...

The effects of FK 506, cyclosporine, and rapamycin on liver growth in vitro and in vivo.

I N ADDITION to immunosuppression. complex and for the most part similar metabolic effects are caused by cyclosporine (CyA) and FK 506. even though these drugs are chemically unrelated and have different cytosolic binding sites (called immunophilins) (Table I). One of the striking nonimmunological effects of Cy A and FK S06 is hepatocyte proliferation. which can be demonstrated in the in vivo m...

FK 506 versus cyclosporine.